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- mouse monoclonal IgM, 200µg/ml
- raised against purified human ULBP2
- recommended for detection of ULBP2 of human origin by IP, IF
- also provided azide-free for blocking, (sc-53135 L), 200 µg/0.1 ml.
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
ULBP2 |
80328 |
6q25.1 |
NM_025217 |
Q9BZM5
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605698 |
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ULBP2 Background Information
Cytomegalovirus UL16 binding proteins, known as ULBPs, are GPI-linked glycoproteins that belong to the extended MHC class I family. ULBP proteins are ligands for the activating receptor, NKG2D/DAP10, which causes lymphocyte activation, resulting in the secretion of cytokines, such as interferon-gamma and tumor cell lysis. ULBPs stimulate cytokine and chemokine production from NK cells, CD8 alpha/beta T cells, and gamma/delta T cells. UL16, binds to three of the five known ligands for human NKG2D. UL16 is retained in the endoplasmic reticulum and cis-Golgi apparatus of cells and causes MICB to be similarly retained and stabilized within cells. Coexpression of UL16 markedly reduces cell surface levels of MICB, ULBP1, and ULBP2, and decreases susceptibility to natural killer cell-mediated cytotoxicity. |
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ULBP2 (6F6)
Click on image to enlarge
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ULBP2 (6F6): sc-53135. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.
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