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- mouse monoclonal IgG1, 200µg/ml
- raised against fusion protein hCD200RCD4d3+4 of human origin
- recommended for detection of OX2R of human origin by FCM
- also provided azide-free for blocking, sc-53102 L, 200 µg/0.1 mlfluorescein (sc-53102 FITC) and phycoerythrin (sc-53102 PE) conjugates for FCM, 100 tests
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OX2R Background Information
OX2 (CD200, MOX2), a member of the immunoglobulin superfamily (IgSF), is a 248 residue cell surface glycoprotein that is expressed in lymphoid cells, neurons, and endothelium. OX2 receptor (OX2R) is a membrane protein with up to 70% of its weight derived from N-linked glycosylation, and it is primarily expressed in lymphoid and neuronal tissue. Phylogenetic analysis of OX2R with respect to other leukocyte IgSF glycoproteins suggests that OXR2 and OX2 share a common ancestral protein. The cytoplasmic portion of OX2R contains NPXY motifs that are known to interact with PTB/PID binding domains. The interaction between OX2 and OX2R may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue. |
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OX2R (OX108)
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OX2R (OX108): sc-53102. Indirect FCM analysis of human peripheral blood leukocytes stained with OX2R (OX108), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG 1: sc-3877. |
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