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Chr-A Antibody (PHE5): sc-53013

 |  Datasheet

(Based on data analysis)
  • Chr-A Antibody (PHE5) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against human pheochromocytoma
  • recommended for detection of chromogranin A of human origin by WB, IP, IF and IHC(P)
 

See additional Chromogranin Antibodies including Chromogranin, Chr-A and Chr-B.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Chr-A Antibody (PHE5) sc-53013 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Chr-A siRNA (h) sc-37212 10 µM $258
Chr-A (h)-PR sc-37212-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Chr-A shRNA Plasmid (h) sc-37212-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Chr-A shRNA (h) Lentiviral Particles sc-37212-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Chr-A (m): 293T Lysate sc-119252 100 µg/200 µl $205
DU 145 Cell Lysate sc-2268 500 µg/200 µl $104
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
SK-N-SH Cell Lysate sc-2410 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CHGA 1113 14q32.12 NM_001275 P10645
 118910
 

Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A), chromogranin B (Chr-B, also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II), secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms; the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.