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home » Tumor Suppressors/Apoptosis » CAD Antibody / CAD Antibodies » CAD (H-1): sc-5295

CAD (H-1) Antibody: sc-5295

  |  Datasheet
  • mouse monoclonal IgG2b; 200 µg/ml
  • raised against amino acids 1-338 of CAD (caspase-activated deoxyribonuclease) of human origin
  • recommended for detection of CAD of human origin by WB, IP, IF, IHC(P) and ELISA
  • agarose conjugate for IP studies, sc-5295 AC, 500 µg/0.25 ml agarose
 
Additional CAD Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human DFFB 1677 1p36.32 NM_001004285, NM_001004286, NM_004402 O76075
 601883
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CAD (H-1) sc-5295 200 µg/ml $279
CAD (H-1) AC sc-5295 AC 500µg/ml, 25%ag $366
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CAD siRNA (h) sc-29871 10 µM $258
CAD (h)-PR sc-29871-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CAD shRNA Plasmid (h) sc-29871-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CAD shRNA (h) Lentiviral Particles sc-29871-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
K-562 nuclear extract sc-2130 1000 µg $143
Jurkat nuclear extract sc-2132 1000 µg $143
LNCaP Cell Lysate sc-2231 500 µg/200 µl $104
Jurkat + PMA nuclear extract sc-2133 1000 µg $143

CAD Background Information
The Ced/ICE or caspase family of cysteine proteases plays a pivotol role in mediating apoptosis through the proteolysis of specific targets. Among the targets are poly(ADP-ribose) polymerase (PARP), Gelsolin, ICAD (inhibitor of CAD, also designated DFF-45) and the nuclear lamins. CAD (caspase-activated deoxyribonuclease), also designated CPAN (caspase-activated nuclease) and DFF40, is a DNase that is responsible for DNA degradation during apoptosis. Caspase-3 acts to dissociate CAD from ICAD, allowing CAD to enter the nucleus and degrade DNA.
CAD (H-1)
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sc-5295
CAD (H-1): sc-5295. Western blot analysis of CAD expression in Jurkat nuclear extract (A) and LNCaP whole cell lysate (B).
sc-5295
CAD (H-1): sc-5295. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver cancer showing cytoplasmic staining of tumor cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
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