Fos B Background Information The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B, which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.
Fos B (83B1138)
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Fos B (83B1138): sc-52926. Western blot analysis of Fos B expression in non-transfected: sc-117752 (A) and human Fos B transfected: sc-112170 (B) 293T whole cell lysates.
Fos B (83B1138): sc-52926. Western blot analysis of Fos B expression in non-transfected: sc-117752 (A) and human Fos B transfected: sc-177246 (B) 293T whole cell lysates.
