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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of HDAC5 of mouse origin
- recommended for detection of HDAC5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
- blocking peptide, sc-5252 P
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HDAC5 Background Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBPassociated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.
| HDAC5 (P-16) Product Citations |
See how others have used HDAC5 (P-16): sc-5252 antibody and or HDAC5 (P-16) antibody conjugates.
5 total citations Loading citations.
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HDAC5 (P-16)
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HDAC5 (P-16): sc-5252. Western blot analysis of HDAC5 expression in Jurkat nuclear extract.
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