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HDAC4 Antibody (N-18): sc-5245

 |  Datasheet

(Based on data analysis)

  • HDAC4 Antibody (N-18) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the N-terminus of HDAC4 of human origin
  • recommended for detection of HDAC4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including avian
  • blocking peptide, sc-5245 P
  • See 6 citations for HDAC4 Antibody (N-18)
 

See additional HDAC Antibodies including HDAC, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10 and HDAC11.

Also see HDAC4 Inhibitors for functional analysis of cellular responses to HDAC4.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
HDAC4 Antibody (N-18) sc-5245 200 µg/ml $279
HDAC4 (N-18) P sc-5245 P
(peptide)
100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HDAC4 siRNA (h) sc-35540 10 µM $258
HDAC4 siRNA (m) sc-35541 10 µM $258
HDAC4 (h)-PR sc-35540-PR 10 µM, 20 µl $23
HDAC4 (m)-PR sc-35541-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HDAC4 shRNA Plasmid (h) sc-35540-SH 20 µg $520
HDAC4 shRNA Plasmid (m) sc-35541-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HDAC4 shRNA (h) Lentiviral Particles sc-35540-V 200 µl $625
HDAC4 shRNA (m) Lentiviral Particles sc-35541-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HDAC4 (h): 293T Lysate sc-115502 100 µg/200 µl $205
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
HeLa nuclear extract sc-2120 250 µg/0.05 ml $143
Jurkat nuclear extract sc-2132 250 µg/0.05 ml $143
NIH/3T3 nuclear extract sc-2138 250 µg/0.05 ml $143
KNRK nuclear extract sc-2141 250 µg/0.05 ml $143
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human HDAC4 9759 2q37.3 NM_006037, XM_001126419 P56524
605314
Mouse Hdac4 208727 1 D Q6NZM9
N/A
 


In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones (1). Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA (1,2). Conversely, the deacetylation of histones is associated with transcriptional silencing (3). Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, p300/CBP, PCAF (p300/CBPassociated factor), HAT1, and the TFIID subunit TAF II p250 (4,5). Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases (6-9).

HDAC4 Antibody (N-18) Product Citations
See how others have used HDAC4 Antibody (N-18) and or HDAC4 Antibody (N-18) conjugates.


6 total citations
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HDAC4 Antibody (N-18) Data
Click on image to enlarge
HDAC4 (N-18): sc-5245. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic and nuclear localization.
HDAC4 (N-18): sc-5245. Western blot analysis of HDAC4 expression in NIH/3T3 (A), HeLa (B) and KNRK (C) nuclear extracts and Jurkat whole cell lysate (D).
HDAC4 (N-18): sc-5245. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tissue showing cytoplasmic staining of glandular cells.
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