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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of AFX1 of human origin
- recommended for detection of AFX1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and porcine
- blocking peptide, sc-5224 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-5224 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
FOXO4 |
4303 |
Xq13.1 |
NM_005938 |
P98177
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300033 |
| Mouse |
Foxo4 |
54601 |
X C3 |
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Q9WVH3
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N/A |
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AFX1 Background Information
FKHR (for forkhead in rhabdomyosarcoma), FKHRL1, and AFX1 are members of a subfamily of the forkhead family of transcription factors. AFX1, also known as FoxO4, is expressed in a wide variety of tissues and, like other FKHR proteins, AFX1 contains a single forkhead domain and serine-proline-rich region, which mediate DNA binding. AFX1-mediated transcriptional activation is regulated by the serine/threonine kinase Akt1, which phosphorylates AFX1 and in turn, sequesters AFX1 in the cytosol, thereby blocking nuclear localization and DNA binding. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. Additionally, the t(x;11) translocation of the AFX1 gene, which involves the fusion of a serine-proline-rich sequence of AFX1 to the carboxy terminus of a truncated MLL, results in acute lymphocytic leukemia.
| AFX1 (C-16) Product Citations |
See how others have used AFX1 (C-16): sc-5224 antibody and or AFX1 (C-16) antibody conjugates.
3 total citations Loading citations.
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AFX1 (C-16)
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AFX1 (C-16): sc-5224. Western blot analysis of AFX1 expression in MM-142 (A), LADMAC (B) and C4 (C) whole cell lysates.
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