Rbx2 Background Information Rbx1 (also designated ROC1 and Hrt1) and the closely related protein Rbx2 (also designated ROC2) are RING finger containing homologs of the yeast protein APC11, a member of the anaphase-promoting complex (APC) (1-4). Rbx1 was shown to be a component of the von Hippel-Lindau (VHL) transcription elongation complex, which includes VHL, Elongin B, Elongin C and Cullin-2 (1). Rbx1 interacts with Cullin-1 in the SCF (Skp1-Cdc53-F-box protein) ubiquitin ligase complex (2-4). Rbx1 functions as a common subunit of SCF complexes required for ubiquination of various proteins including yeast G1 cyclins, IkBa and b-catenin (2-4). Rbx1 was shown to enhance the ubiquitin ligase activity of the VHL/Cullin-2 complex, and of the SCF/Cullin-1 complex (5).
Rbx2 (N-15) Product Citations
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Rbx2 (N-15)
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Rbx2 (N-15): sc-5203. Western blot analysis of Rbx2 expression in non-transfected: sc-110760 (A) and human Rbx2 transfected: sc-110905 (B) 293 whole cell lysates.
Rbx2 (N-15): sc-5203. Western blot analysis of Rbx2 expression in non-transfected: sc-117752 (A) and mouse Rbx2 transfected: sc-123029 (B) 293T whole cell lysates.
