Thyroglobulin Antibody (2H11): sc-51708

Thyroglobulin Antibody (2H11) is a mouse monoclonal IgG1 antibody that detects thyroglobulin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Thyroglobulin is a large preprotein that plays a crucial role in the synthesis of the iodinated thyroid hormones thyroxine and triiodothyronine, which are essential for regulating metabolism, growth, and development. Anti-thyroglobulin antibody (2H11) targets proteins primarily located in the thyroid gland, where thyroglobulin serves as a precursor that undergoes complex post-translational modifications, including glycosylation, which are vital for stability and function. These modifications not only facilitate proper folding and maturation of thyroglobulin but also influence interaction with other proteins involved in hormone synthesis. Defects in thyroglobulin can lead to various thyroid disorders, including goiter, which is characterized by the enlargement of the thyroid gland due to impaired dimerization and transport of thyroglobulin to the Golgi complex. Thyroglobulin monoclonal antibody (2H11) is an invaluable tool for researchers studying thyroid function and related pathologies, providing insights into the molecular mechanisms underlying thyroid hormone production and regulation.

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Thyroglobulin Antibody (2H11) References:

1. Measuring thyroglobulin and thyroglobulin autoantibody in patients with differentiated thyroid cancer.  |  Spencer, CA. and Lopresti, JS. 2008. Nat Clin Pract Endocrinol Metab. 4: 223-33. PMID: 18268520
2. Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis.  |  Carayanniotis, G. 2011. Hormones (Athens). 10: 27-35. PMID: 21349803
3. Thyroglobulin gene mutations in congenital hypothyroidism.  |  Targovnik, HM., et al. 2011. Horm Res Paediatr. 75: 311-21. PMID: 21372558
4. Intrinsic regulation of thyroid function by thyroglobulin.  |  Sellitti, DF. and Suzuki, K. 2014. Thyroid. 24: 625-38. PMID: 24251883
5. Use of thyroglobulin as a tumour marker.  |  Indrasena, BS. 2017. World J Biol Chem. 8: 81-85. PMID: 28289520
6. The role of thyroglobulin in thyroid hormonogenesis.  |  Citterio, CE., et al. 2019. Nat Rev Endocrinol. 15: 323-338. PMID: 30886364
7. Normal and defective expression of the thyroglobulin gene.  |  Vassart, G., et al. 1987. Horm Res. 26: 8-11. PMID: 3297966
8. Serum thyroglobulin is associated with orbitopathy in Graves' disease.  |  Khamisi, S., et al. 2021. J Endocrinol Invest. 44: 1905-1911. PMID: 33515213
9. Impact of Thyroglobulin and Thyroglobulin Antibody Assay Performance on the Differential Classification of DTC Patients.  |  Schoonen, L., et al. 2022. J Endocr Soc. 6: bvab166. PMID: 35024538
10. Structural features of thyroglobulin linked to protein trafficking.  |  Citterio, CE., et al. 2023. Protein Sci. 32: e4784. PMID: 37717261

The preferred Thyroglobulin antibody is Thyroglobulin Antibody (D-9): sc-365997.