Cytokeratin 18 Antibody (C-04): sc-51582

Cytokeratin 18 Antibody (C-04) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cytokeratin 18 in mouse, rat, human, bovine, porcine, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Cytokeratin 18 antibody (C-04) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cytokeratin 18, also known as KRT18, is a vital component of the cytoskeleton in epithelial cells, playing a crucial role in maintaining cell integrity and providing mechanical support. KRT18 is primarily located in the cytoplasm of epithelial cells, where proper localization is essential for cellular architecture and function. Disruption of KRT18 localization can lead to compromised cell stability and has been implicated in various pathological conditions, including cancer. KRT18 serves as a significant marker for adenocarcinomas and basal cell carcinomas, making KRT18 an important target for cancer diagnostics and research. Additionally, KRT18 undergoes post-translational modifications, including phosphorylation at specific serine residues, which are critical for interaction with other proteins, such as 14-3-3 proteins, influencing keratin organization and distribution within the cell.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 18 Antibody (C-04) has 63 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 18 Antibody (C-04) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 18 Antibody (C-04) Specifications

Alternate Product Name: KRT18

Product Clone Name: C-04

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Cytokeratin 18

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 18

Species Reactivity/Detection: mouse, rat, human, bovine, porcine, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 63 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 18 Antibody (C-04): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Cytokeratin 18 antibody is Cytokeratin 18 Antibody (RGE53): sc-32329.