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home » Kinases and Phosphatases » JAK Antibody / JAK Antibodies » JAK3 (C-21): sc-513

JAK3 (C-21) Antibody: sc-513

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope mapping at the C-terminus of JAK3 of human origin
  • recommended for detection of JAK3 of human origin by WB, IP, IF and ELISA
  • blocking peptide, sc-513 P
  • TransCruz reagent for ChIP application, sc-513 X, 200 µg/0.1 ml
  • agarose conjugate for IP studies, sc-513 AC, 500 µg/0.25 ml agarose
 
Additional JAK Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human JAK3 3718 19p13.11 NM_000215 P52333
 600173
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
JAK3 (C-21) sc-513 200 µg/ml $279
JAK3 (C-21) AC sc-513 AC 500µg/ml, 25%ag $366
JAK3 (C-21) P sc-513 P
(peptide)
 100 µg/0.5 ml $61
JAK3 (C-21) X sc-513 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
JAK3 siRNA (h) sc-29379 10 µM $258
JAK3 (h)-PR sc-29379-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
JAK3 shRNA Plasmid (h) sc-29379-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
JAK3 shRNA (h) Lentiviral Particles sc-29379-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HuT 78 Whole Cell Lysate sc-2208 500 µg/200 µl $104
MOLT-4 Cell Lysate sc-2233 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

JAK3 Background Information
JAK3 (Janus kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

JAK3 (C-21) Product Citations
See how others have used JAK3 (C-21): sc-513 antibody and or JAK3 (C-21) antibody conjugates.


43 total citations
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JAK3 (C-21)
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sc-513
JAK3 (C-21): sc-513. Western blot analysis of JAK3 expression in HuT 78 (A) and MOLT-4 (B) whole cell lysates.
sc-513
Western blot analysis of JAK3 expression in HeLa whole cell lysates (A,B). Antibodies tested include JAK3 (B-12): sc-6932 (A) and JAK3 (C-21): sc-513 (B).
sc-513
JAK3 (C-21): sc-513. Western blot analysis of JAK3 expression in HuT 78 whole cell lysate.
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