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- goat polyclonal IgG, 200µg/ml
- epitope mapping near the C-terminus of HIP2 of human origin
- recommended for detection of HIP2 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-50733 P
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HIP2 |
3093 |
4p14 |
NM_005339 |
P61086
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602846 |
| Mouse |
Ube2k |
53323 |
5 C3.1 |
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P61087
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N/A |
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HIP2 Background Information
HIP1 (Huntingtin interacting protein 1), a membrane-associated protein, and HIP2 bind specifically to the N-terminus of human Huntingtin. HIP1 and HIP2 are ubiquitously expressed in different brain regions at low levels and exhibit nearly identical subcellular fractionation as Huntingtin. The Huntingtin-HIP1 interaction is inversely correlated to the polyglutamine length in Huntingtin, suggesting that loss of normal Huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. Conversely, the Huntingtin-HIP2 interaction is not affected by the polyglutamine length in the Huntingtin protein. However, both HIP1 and HIP2 play an important role in the pathogenesis of Huntington disease (HD). |
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HIP2 (A-15)
Click on image to enlarge
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HIP2 (A-15): sc-50733. Western blot analysis of HIP2 expression in Jurkat whole cell lysate.
HIP2 (A-15): sc-50733. Western blot analysis of HIP2 expression in non-transfected: sc-117752 (A) and human HIP2 transfected: sc-116355 (B) 293T whole cell lysates. HIP2 (A-15): sc-50733. Western blot analysis of HIP2 expression in non-transfected: sc-117752 (A) and mouse HIP2 transfected: sc-120787 (B) 293T whole cell lysates. HIP2 (A-15): sc-50733. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing nuclear and cytoplasmic staining of cells in red and white pulps in low (A) and high (B) resolution. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
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