epitope mapping within an internal region of XRN1 of human origin
recommended for detection of XRN1 of mouse, rat and human origin by WB, IF and ELISA; not recommended for isoform 3; also reactive with additional species, including equine, canine, bovine, porcine and avian
XRN1 Background Information Degradation of mRNA is a critical aspect of gene expression that occurs via the exoribonuclease. Exoribonuclease I (XRN1), also known as Sep1 or Rar5, is a 1,694-amino acid protein that functions as the major cytoplasmic 5 prime to 3 prime exoribonuclease and plays an important role in mRNA turnover. XRN1 may also function in the microtubular cytoskeleton as well as in DNA recombination and replication. XRN1 induces the expression of stress granules (SGs), cytoplasmic aggregates of stalled translational preinitiation complexes that accumulate during stress, and GW bodies/processing bodies (PBs), distinct cytoplasmic sites of mRNA degradation. Loss of XRN1 markedly affects cell growth rates.
