epitope mapping within an internal region of XK of human origin
recommended for detection of XK of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
XK Background Information Kell and XK are two covalently linked plasma membrane proteins that constitute the Kell blood group system, a group of antigens on the surface of red blood cells that are important determinants of blood type and targets for autoimmune or alloimmune diseases. XK is a 444 amino acid protein that spans the membrane 10 times and carries the ubiquitous antigen, Kx, which determines blood type. XK also plays a role in the sodium-dependent membrane transport of oligopeptides and neutral amino acids. XK is expressed at high levels in brain, heart, skeletal muscle and pancreas. Defects in the XK gene cause McLeod syndrome (MLS), an X-linked multisystem disorder characterized by abnormalities in neuromuscular and hematopoietic system such as acanthocytic red blood cells and late-onset forms of muscular dystrophy with nerve abnormalities.
