epitope mapping near the N-terminus of NPAS1 of human origin
recommended for detection of NPAS1 (Neuronal PAS domain protein 1) of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine and porcine
NPAS1 Background Information Members of the bHLH-PAS family are transcription factors that contain a basic helix-loop-helix (bHLH) DNA-recognition motif which is located N-terminal to a PAS domain comprised of two imperfect direct repeats. Human NPAS1 is a deduced 590-amino acid protein which shares 86% sequence homology with mouse Npas1. In order for NPAS1 to bind DNA efficiently, it must form a dimer with another bHLH protein. NPAS1 interacts with ARNT (aryl hydrocarbon receptor nuclear translocator), and shows predominant expression in brain tissue. NPAS1 is also implicated in the control of regulatory pathways relevant to schizophrenia and to psychotic illness, and may play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen levels. The NPAS1 gene maps to human chromosome 19q13.2-q13.3.
