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- goat polyclonal IgG, 200µg/ml
- epitope mapping within an internal region of IRSp53 of human origin
- recommended for detection of IRSp53 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-50011 P
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Ordering Information
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IRSp53 Background Information
The scaffolding protein insulin receptor tyrosine kinase substrate p53 (IRSp53), a ubiquitous regulator of the Actin cytoskeleton, mediates filopodia formation under the control of Rho-family GTPases. It is expressed in the cytoplasm and links small membrane-bound G-proteins to cytoplasmic effector proteins. IRSp53 comprises a central SH3 domain, which binds to proline-rich regions of a wide range of Actin regulators, and a conserved N-terminal IRSp53/MIM homology domain (IMD) that harbors F-Actin-bundling activity. IRSp53 inter-acts with atrophin-1, the product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene, which is associated with an autosomal dominant neurodegenerative disease. The IRSp53 protein also interacts with ENAH, BAI-1, Eps8, Shank 1, Shank 2, Shank 3, WAVE1, WAVE2, Tiam1 and Dia 1. |
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IRSp53 (W-20)
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IRSp53 (W-20): sc-50011. Western blot analysis of IRSp53 expression in non-transfected 293T: sc-117752 (A), human IRSp53 transfected 293T: sc-115292 (B) and K-562 (C) whole cell lysates. IRSp53 (W-20): sc-50011. Western blot analysis of IRSp53 expression in non-transfected 293T: sc-117752 (A), human IRSp53 transfected 293T: sc-115292 (B) and K-562 (C) whole cell lysates. |
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