Vasohibin-1 (E-17) Antibody: sc-49777

Vasohibin-1 Background Information
Angiogenesis is mainly regulated by the balance of several different pro-angiogenic stimulators, such as vascular endothelial growth factor (VEGF) and a diverse group of endogenous inhibitors that are extrinsic to endothelial cells. Vasohibin is a secreted protein that is induced by a specific, self-regulating, feedback inhibition response to inhibit angiogenesis in an autocrine manner. It inhibits proliferation, migration, and network formation by endothelial cells. This function is specific for endothelial cells as it does not affect migration in other cell types. Vasohibin is primarily expressed in endothelial of the brain and placental tissues with highest abundance in fetal organs. VEGF and fibroblast growth factor 2 upregulate the expression of Vasohobin. In vitro, Vasohibin does not affect cancer cell proliferation, but does inhibit tumor growth and angiogenesis.