epitope mapping at the N-terminus of ABCE1 of human origin
recommended for detection of ABCE1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
ABCE1 Background Information ABCE1 (RNS4I, RLI) is a mediator of the 2-5A/RNase L pathway. The 2-5A/ RNase L system is considered an essential pathway of interferon (IFN) action. In the pathway, IFN stimulation activates 2-5A synthetases which convert ATP into a set of atypical oligomers known as 2-5A. These oligomers in turn activate RNase L (RNS4), which leads to inhibition of protein synthesis by cleaving mRNAs at the 3-prime side of UpNp sequences. This inhibition ne-cessitates the association of ABCE1 with RNase L and is dependent on the ratio between the two proteins. The 2-5A/RNase L system could also play a more general physiological role, for instance, in the regulation of RNA stability in mammalian cells.
ABCE1 (N-12)
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ABCE1 (N-12): sc-49338. Western blot analysis of ABCE1 expression in non-transfected: sc-117752 (A) and mouse ABCE1 transfected: sc-118158 (B) 293T whole cell lysates.
ABCE1 (N-12): sc-49338. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
