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home » Transcription Regulators » Pontin Antibody / Pontin Antibodies » Pontin 52 (E-18): sc-49076

Pontin 52 (E-18) Antibody: sc-49076

  |  Datasheet
  • goat polyclonal IgG, 200µg/ml
  • epitope mapping within an internal region of Pontin 52 of human origin
  • recommended for detection of Pontin 52 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-49076 X, 200 µg/0.1 ml
  • blocking peptide, sc-49076 P
 
Additional Pontin Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human RUVBL1 8607 3q21.3 NM_003707 Q9Y265
 603449
Mouse Ruvbl1 56505 6 D1 P60122
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Pontin 52 (E-18) sc-49076 200 µg/ml $279
Pontin 52 (E-18) P sc-49076 P
(peptide)
 100 µg/0.5 ml $61
Pontin 52 (E-18) X sc-49076 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Pontin 52 siRNA (h) sc-43543 10 µM $258
Pontin 52 siRNA (m) sc-60010 10 µM $258
Pontin 52 (h)-PR sc-43543-PR 10 µM $23
Pontin 52 (m)-PR sc-60010-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Pontin 52 shRNA Plasmid (h) sc-43543-SH 20 µg $520
Pontin 52 shRNA Plasmid (m) sc-60010-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Pontin 52 shRNA (h) Lentiviral Particles sc-43543-V 200 µl $625
Pontin 52 shRNA (m) Lentiviral Particles sc-60010-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SK-BR-3 nuclear extract sc-2134 1000 µg $143
K-562 nuclear extract sc-2130 1000 µg $143
KNRK nuclear extract sc-2141 1000 µg $143
NIH/3T3 nuclear extract sc-2138 1000 µg $143
SK-BR-3 Cell Lysate sc-2218 500 µg/200 µl $104
Pontin 52 (h2): 293T Lysate sc-175102 100µg/200µl $205

Pontin 52 Background Information
Pontin 52 is nuclear matrix protein that is primarily expressed in the nucleus and is also present in the cytoplasm. Pontin 52 is expressed in the nucleoplasm of whole cells, but is not present in the nucleoli. Pontin 52 is also designated RUVBL1, for E. coli RuvB-like 1 protein, or NMP 238, and is the human homolog of rat TIP49. Pontin 52 contains an ATPase/helicase motif and may represent a class of cofactors recruited by transcriptional activation domains that function in diverse pathways. For instance, in vivo, Pontin 52 is complexed with Myc and Reptin 52, which is a Pontin 52 related protein also designated RUVBL2. The interaction of Pontin 52 with Myc is dependent upon a Myc domain essential for oncogenic activity, suggesting that functional Pontin 52 is an essential mediator of Myc oncogenic transformation. The gene encoding human Pontin 52 maps to chromosome 3q21.

Pontin 52 (E-18)
Click on image to enlarge
sc-49076
Pontin 52 (E-18): sc-49076. Western blot analysis of Pontin 52 expression in K-562 nuclear extract.
sc-49076
Pontin 52 (E-18): sc-49076. Western blot analysis of Pontin 52 expression in SK-BR-3 whole cell lysate.
sc-49076
Pontin 52 (E-18): sc-49076. Western blot analysis of Pontin 52 expression in non-transfected: sc-117752 (A) and human Pontin 52 transfected: sc-113069 (B) 293T whole cell lysates.
sc-49076
Pontin 52 (E-18): sc-49076. Western blot analysis of Pontin 52 expression in non-transfected 293T: sc-117752 (A), human Pontin 52 transfected 293T: sc-175102 (B) and SKBR-3 (C) whole cell lysates.
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