epitope mapping near the C-terminus of Cochlin of human origin
recommended for detection of Cochlin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
Cochlin Background Information Cochlin is a secreted protein encoded by the coagulation factor C homology (COCH) gene, a cochlear gene. It constitutes 70% of the inner ear proteins and is classified into three glycosylated isoforms: p63s, p44s and p40. Cochlin contains an N-terminal LCCL domain and two von Willebrand factor A-like domains. Mutations in the COCH gene cause DFNA9, an autosomal dominant nonsyndromic auditory and vestibular dysfunction disorder, as a result of either an amino acid deletion in the LCCL domain or missense substitutions. Microfibrillar deposits accumulate in the inner ear of individuals with DFNA9 and these deposits may contain the Cochlin protein. Cochlin is a target antigen for autoimmune sensorineural hearing loss.
Cochlin (D-19)
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Cochlin (D-19): sc-48976. Western blot analysis of Cochlin expression in mouse eye tissue extract.
