 |
- goat polyclonal IgG, 200µg/ml
- epitope mapping at the N-terminus of BRE of human origin
- recommended for detection of BRE of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
- TransCruz reagent for Gel Supershift and ChIP applications, sc-48849 X, 200 µg/0.1 ml
- blocking peptide, sc-48849 P
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
BRE Background Information
Brain and reproductive organ-expressed protein (BRE) is a 415 amino acid protein which binds to the intracellular juxtamembrane domain of the death receptor, tumor necrosis factor receptor 1 (TNF-R1). BRE also binds to the death receptor, FAS. BRE downregulates TNFa-induced activation of NFkB and may play a role in homeostasis or cellular differentiation in cells of epithelial, neural and germ line origins. It inhibits components of the death-inducing signaling complexes that are necessary for activation of the mitochondria, thereby mediating apoptosis. BRE is strongly expressed in the adrenal cortex, medulla, testis and pancreas, and is weakly expressed in the thymus, thyroid, stomach and small intestine. The BRE gene is responsive to DNA-damaging agents in fibroblasts, LPS in peripheral blood mononuclear cells (PBMC), and by retinoic acid in brain gloima. |
|
|
BRE (N-12)
Click on image to enlarge
|
BRE (N-12): sc-48849. Western blot analysis of BRE expression in non-transfected: sc-110760 (A) and human BRE transfected: sc-110575 (B) 293 whole cell lysates. BRE (N-12): sc-48849. Western blot analysis of BRE expression in non-transfected: sc-110760 (A) and human BRE transfected: sc-110575 (B) 293 whole cell lysates. BRE (N-12): sc-48849. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
|
|
Download
|
|
