 |
Aprataxin (E-17) Antibody: sc-48840 |
| Datasheet |
|
- goat polyclonal IgG, 200µg/ml
- epitope mapping within an internal region of Aprataxin of human origin
- recommended for detection of Aprataxin isoforms 1, 3, 4, 5, 7 and 9 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- TransCruz reagent for Gel Supershift and ChIP applications, sc-48840 X, 200 µg/0.1 ml
- blocking peptide, sc-48840 P
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
Aprataxin Background Information
Aprataxin is a nuclear protein, present in both the nucleoplasm and the nucleolus, which is a member of the histidine triad (HIT) superfamily. Aprataxin is involved in DNA single-strand break repair, mediating protein-protein interactions with molecules responding to DNA damage. Aprataxin contains three conserved domains: an N-terminal forkhead-associated (FHA) domain which mediates protein-protein interactions, a HIT domain that is similar to Hint, and a C-terminal zinc finger domain. Loss of function mutations in APTX, the gene encoding for Aprataxin, destabilize the Aprataxin protein and result in a rare neurological disorder known as ataxia-oculomotor apraxia, characterized by abnormal movements of the head and eyes. These mutations either target the HIT domain or truncate the protein N-terminal to a zinc finger. |
|
|
Aprataxin (E-17)
Click on image to enlarge
|
Aprataxin (E-17): sc-48840. Western blot analysis of Aprataxin expression in non-transfected: sc-117752 (A) and mouse Aprataxin transfected: sc-124980 (B) 293T whole cell lysates. Aprataxin (E-17): sc-48840. Western blot analysis of Aprataxin expression in HeLa nuclear extract.
|
|
Download
|
|
