epitope corresponding to amino acids 311-450 mapping near the C-terminus of Sox-10 of human origin
recommended for detection of Sox-10 and, to a lesser extent, Sox-9 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-48824 X, 200 µg/0.1 ml
Sox-10 Background Information Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Sox-10 (H-140)
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Sox-10 (H-140): sc-48824. Western blot analysis of Sox-10 expression in mouse brain tissue extract.
Sox-10 (H-140): sc-48824. Western blot analysis of Sox-10 expression in non-transfected: sc-117752 (A) and mouse Sox-10 transfected: sc-123716 (B) 293T whole cell lysates and mouse brain tissue extract (C).
Sox-10 (H-140): sc-48824. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
