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home » Transcription Regulators » DNA Polymerase Antibody / DNA Polymerase Antibodies » DNA pol α (H-230): sc-48818

DNA pol α (H-230) Antibody: sc-48818

  |  Datasheet
  • rabbit polyclonal IgG, 200µg/ml
  • epitope corresponding to amino acids 1211-1440 mapping near the C-terminus of DNA pol α of human origin
  • recommended for detection of DNA pol α of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
 
Additional DNA Polymerase Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human POLA1 5422 Xp22.11 NM_016937 P09884
 312040
Mouse Pola1 18968 X C3 P33609
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
DNA pol α (H-230) sc-48818 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
DNA pol α siRNA (h) sc-37771 10 µM $258
DNA pol α siRNA (m) sc-37772 10 µM $258
DNA pol α (h)-PR sc-37771-PR 10 µM $23
DNA pol α (m)-PR sc-37772-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
DNA pol α shRNA Plasmid (h) sc-37771-SH 20 µg $520
DNA pol α shRNA Plasmid (m) sc-37772-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
DNA pol α shRNA (h) Lentiviral Particles sc-37771-V 200 µl $625
DNA pol α shRNA (m) Lentiviral Particles sc-37772-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Jurkat nuclear extract sc-2132 1000 µg $143
K-562 nuclear extract sc-2130 1000 µg $143
KNRK nuclear extract sc-2141 1000 µg $143

DNA pol α Background Information
DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol å, ∫, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits: p125, which interacts with the sliding DNA clamp protein PCNA; and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol † is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8).