TAZ Background Information The transcriptional co-activator with PDZ-binding motif (TAZ) is a 14-3-3-binding molecule. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. TAZ may link events at the plasma membrane and cytosketeton to nuclear transcription in a manner that can be regulated by 14-3-3. TAZ shares homology with the WW domain of Yes-associated protein (YAP) and functions as a transcriptional co-activator by binding to the PPXY motif present on transcription factors. TAZ recognizes immunoreactive protein bands in lysates from MDCK, NIH-3T3 and 293T cells. In addition, COS7, Hep G2, CHO and HeLa cells express endogenous TAZ. 14-3-3 binding requires TAZ phosphorylation on a single Serine 89 residue, resulting in the inhibition of TAZ transcriptional co-activation through 14-3-3-mediated nuclear export.
TAZ (H-70) Product Citations
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TAZ (H-70)
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TAZ (H-70): sc-48805. Immunofluorescence staining of normal mouse liver frozen section showing nuclear staining.
TAZ (H-70): sc-48805. Immunoperoxidase staining of formalin fixed, paraffin-embedded human corpus, uterine tissue showing nuclear and cytoplasmic staining of cells in endometrial stroma and glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
TAZ (H-70): sc-48805. Western blot analysis of TAZ expression in HeLa whole cell lysate.
