epitope corresponding to amino acids 471-570 mapping near the C-terminus of MTA3 of human origin
recommended for detection of MTA3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
TransCruz reagent for Gel Supershift and ChIP applications, sc-48799 X, 200 µg/0.1 ml
MTA3 Background Information Metastasis-associated protein 3 (MTA3) is a subunit of the Mi-2/NuRD transcriptional corepressor complex. MTA3 and the Mi-2/NuRD complex mediate repression of Snail in breast cancer cells where MTA3 works to maintain a differentiated, epithelial status. The protein is involved in gene expression regulation by covalent modifications of histone proteins. There are two known isoforms of MTA3, a short and a long form. The short isoform binds to ER and sequesters it to the cytoplasm and betters non-genomic responses, whereas the long form is found in the nucleus. MTA3 is widely expressed in with highest expression in brain, adrenal glands, ovaries and virgin mammary glands. It has been found to be expressed in higher levels in tumors than in adjacent normal tissue in the same individual.
MTA3 (H-100) Product Citations
See how others have used MTA3 (H-100): sc-48799 antibody and or MTA3 (H-100) antibody conjugates.
