Claspin Background Information Claspin, an essential replication checkpoint control protein, regulates the interaction between Chk1 and the upstream regulatory kinase ATR. Chk1 mediates cell cycle arrest in response to a block in DNA replication or to DNA damage by ultraviolet radiation. Claspin becomes phosphorylated within its Chk1 binding domain in response to replication stress. This domain consists of two highly conserved repeats of approximately ten amino acids. Each repeat contains a serine residue (serine 864 and serine 895) that undergoes phosphorylation. Binding of Chk1 and Claspin promotes the interaction between Chk1 and ATR and Rad9, thereby arresting the cell cycle. Claspin is most abundant within cells at the S/G2 phase.
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Claspin (H-300)
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Claspin (H-300): sc-48771. Western blot analysis of Claspin expression in non-transfected: sc-117752 (A) and mouse Claspin transfected: sc-125137 (B) 293T whole cell lysates.
Claspin (H-300): sc-48771. Western blot analysis of Claspin expression in non-transfected: sc-117752 (A) and mouse Claspin transfected: sc-125137 (B) 293T whole cell lysates.
