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- goat polyclonal IgG, 200µg/ml
- epitope mapping within an internal region of VAP-A of human origin
- recommended for detection of VAP-A of mouse, rat, human and dog origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
- blocking peptide, sc-48698 P
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VAP-A Background Information
SNAREs are compartmentally specific, integral membrane proteins that are involved in the fusion of membranes and the transport of intracellular proteins. SNAREs are expressed at high levels in all cell types. VAMP-associated protein A (VAP-A) is a SNARE regulator with high levels of expression in the intestine during late embryogenesis and early neonatal development. VAP-A binds to a wide range of SNAREs and fusion-related proteins, including Syntaxin 1A, rBet1, rSec22, åSNAP and NSF. This suggests that VAP-A may play a more general role in SNARE-mediated vesicle traffic between the ER and Golgi in nonpolarized cells. VAP-A also mediates traffic in cell membranes and may play an important role in modulating intestinal smooth muscle cell differentiation. VAP-A and p48 interact to form a stable complex in mammalian cells. |
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VAP-A (K-15)
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VAP-A (K-15): sc-48698. Western blot analysis of VAP-A expression in MDCK (A), HeLa (B) and NIH/3T3 (C) whole cell lysates.
VAP-A (K-15): sc-48698. Western blot analysis of VAP-A expression in non-transfected 293T: sc-117752 (A), mouse VAP-A transfected 293T: sc-124538 (B) and HeLa (C) whole cell lysates. VAP-A (K-15): sc-48698. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
VAP-A (K-15): sc-48698. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
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