Welcome to Santa Cruz Biotechnology!

GCH-I Antibody (K-15): sc-48510

 |  Datasheet

(Based on data analysis)

  • GCH-I Antibody (K-15) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the C-terminus of GCH-I of human origin
  • recommended for detection of GCH-I isoform GCH-1 only of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-48510 P
  • See 2 citations for GCH-I Antibody (K-15)

See additional GCH-I Antibodies.

Also see chemical GCH-I Inhibitors for functional analysis of cellular responses to GCH-I.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GCH-I Antibody (K-15) sc-48510 200 µg/ml $279
GCH-I (K-15) P sc-48510 P
100 µg/0.5 ml $61
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GCH-I CRISPR/Cas9 KO Plasmid (h) sc-402386 20 µg $345
GCH-I HDR Plasmid (h) sc-402386-HDR 20 µg $385
GCH-I CRISPR/Cas9 KO Plasmid (m) sc-420509 20 µg $345
GCH-I HDR Plasmid (m) sc-420509-HDR 20 µg $385
 CRISPR Activation Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GCH-I CRISPR Activation Plasmid (h) sc-402386-ACT 20 µg $345
GCH-I CRISPR Activation Plasmid (m) sc-420509-ACT 20 µg $345
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GCH-I siRNA (h) sc-60675 10 µM $258
GCH-I siRNA (m) sc-60676 10 µM $258
GCH-I (h)-PR sc-60675-PR 10 µM, 20 µl $23
GCH-I (m)-PR sc-60676-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GCH-I shRNA Plasmid (h) sc-60675-SH 20 µg $520
GCH-I shRNA Plasmid (m) sc-60676-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GCH-I shRNA (h) Lentiviral Particles sc-60675-V 200 µl $625
GCH-I shRNA (m) Lentiviral Particles sc-60676-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IMR-32 Cell Lysate sc-2409 500 µg/200 µl $104
GCH-I (m): 293T Lysate sc-120450 100 µg/200 µl $205
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GCH1 2643 14q22.2 NM_000161, NM_001024024, NM_001024070, NM_001024071 P30793
Mouse Gch1 14528 14 C1 Q05915

GTP cyclohydrolase I (GCH-I), a homodecamer, catalyzes the conversion of GTP into dihydroneopterin triphosphate and folate. GCH-I is the the first and rate limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis. BH4 is the cofactor for tyrosine hydroxylase, a rate-limiting enzyme for dopamine synthesis, and tryptophan hydroxylase, the rate-limiting enzyme for serotonin biosynthesis. Dopamine and serotonin are neurotransmitters involved in depression, which may be associated with a deficiency of BH4. Mutations in the gene encoding GCH-I cause malignant hyperphenylalaninemia, a genetic neurological disorder characterized by abnormally high levels of serum phenylalanine, and dopa-responsive dystonia (DRD), a group of movement disorders characterized by a progressive difficulty in walking which respond to L-dopa.

GCH-I Antibody (K-15) Product Citations
See how others have used GCH-I Antibody (K-15) and or GCH-I Antibody (K-15) conjugates.

2 total citations
Loading citations.
GCH-I Antibody (K-15) Data
Click on image to enlarge
GCH-I (K-15): sc-48510. Western blot analysis of GCH-I expression in non-transfected: sc-117752 (A) and mouse GCH-I transfected: sc-120450 (B) 293T whole cell lysates.
GCH-I (K-15): sc-48510. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix tissue showing cytoplasmic staining of squamous epithelial cells.