epitope mapping at the N-terminus of ABCA3 of human origin
recommended for detection of ABCA3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
ABCA3 Background Information The ATP binding cassette (ABC) transporters, or traffic ATPases, constitute an expansive family of proteins accountable for the transport of a wide variety of substrates across cell membranes in both prokaryotic and eukaryotic cells and are involved in the regulation of lipid transport and membrane trafficking. ABCA3 (ATP-binding cassette 3), also designated ATP-binding cassette transporter 3 and ABC transporter 3, has typical structural features of the ABC transporter family and consists of a 1,704 amino acid polypeptide with two homologous repeats, each consisting of six putative transmembrane helices and an ATP-binding cassette motif. ABCA3, the gene encoding the human ABCA3 protein, maps near the polycystic kidney disease type 1 (PKD1) gene on chromosome 16p13.3. The ABCA3 gene is expressed at highest levels in lung. Biochemical and molecular research indicates that ABCA3 is targeted to vesicle membranes and located in the limiting membrane of lamellar bodies and may play a key role in lipid organization during the formation of lamellar bodies.
ABCA3 (N-20)
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ABCA3 (N-20): sc-48444. Western blot analysis of ABCA3 expression in HeLa whole cell lysate.
