RPA194 Background Information RNA polymerases transcribe nuclear genes for ribosomal RNA, thus representing ribosomal biogenesis. RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes, which code for large ribosomal RNA. Different subunits of the Pol I transcription machinery are targets of various physiological stimuli, which suggests that multiple signaling pathways are involved in carrying out Pol I transcription. RPA40 and RPA16 are subunits of Pol I that associate with each other at an early stage of RNA polymerase I assembly. RPA40 is essential for the function and integrity of the complex and is also an essential subunit of RNA polymerase III (Pol III). RPA40, RPA16 and RPA135 encode the three subunits of RNA polymerase I, respectively. RPA194 is the largest subunit of RNA Pol I and is not a component of Pol II and Pol III.
RPA194 (C-1) Product Citations
See how others have used RPA194 (C-1): sc-48385 antibody and or RPA194 (C-1) antibody conjugates.
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RPA194 (C-1)
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RPA194 (C-1): sc-48385. Western blot analysis of RPA194 expression in HeLa whole cell lysate (A) and KNRK nuclear extract (B).
RPA194 (C-1): sc-48385. Immunofluorescence staining of methanol-fixed HeLa cells showing nucleolar localization.
RPA194 (C-1): sc-48385. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing nuclear staining of surface epthelial and non-follicle cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
RPA194 (C-1): sc-48385. Western blot analysis of RPA194 expression in non-transfected 293T: sc-117752 (A), truncated human RPA194 transfected 293T: sc-111445 (B) and KNRK (C) whole cell lysates.
RPA194 (C-1): sc-48385. Immunofluorescence staining of methanol-fixed HeLa cells showing nucleolar localization.
