RelB (D-4) Antibody: sc-48366

RelB Background Information
The NF˚B transcription factor was originally identified as a protein complex consisting of a DNA binding subunit and an associated protein. The DNA binding subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino terminus of a precursor designated p105. A second protein designated p52 (previously referred to as p49) has been identified that can act as an alternative NF˚B subunit. Rel B does not bind with high affinity to NFkB sites, but heterodimers between Rel B and p50 bind with an affinity comparable to that of p50 NF˚B homodimers. However, Rel B/p50 heterodimers, in contrast to NF˚B heterodimers, transactivates transcription of promotors containing ˚B binding sites.