Stat3 Background Information Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
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Stat3 (C-20)
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Stat3 (C-20): sc-482. Western blot analysis of Stat3 expression in K-562 (A), 3611-RF (B), NIH/3T3 (C) and KNRK (D) whole cell lysates.
Stat3 (C-20): sc-482. Western blot analysis of Stat3 expression in non-transfected: sc-117752 (A) and human Stat3 transfected: sc-129869 (B) 293T whole cell lysates.
Stat3 (C-20): sc-482. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.
