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- goat polyclonal IgG, 200µg/ml
- epitope mapping near the N-terminus of ELKS of human origin
- recommended for detection of ELKS of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- TransCruz reagent for Gel Supershift and ChIP applications, sc-47876 X, 200 µg/0.1 ml
- blocking peptide, sc-47876 P
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Ordering Information
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ELKS Background Information
The glutamine, leucine, lysine, and serine-rich protein ELKS, also designated Rab6-interacting protein 2 and CAZ-associated structural protein (CAST) or the acronym ERC, is a member of a family of RIM-binding proteins. RIMs are presynaptic active zone proteins that regulate neurotransmitter release. This class of protein functions by recruiting I˚Bå to the I˚B kinase (IKK) complex, and thus serves a regulatory function for IKK activation. Five isoforms of ELKS (Alpha, Beta, Gamma, Delta, and Epsilon) exist and have multiple coding region differences and distinct C-termini. Only brain-specific ELKS bind to RIMs, but both ubiquitous and brain-specific ELKS bind to Rab6, a GTP-binding protein involved in membrane traffic at the Golgi complex. Fusion of ELKS to RET due to translocation t(10;12)(q11;p13) results in a papillary thyroid carcinoma. |
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ELKS (N-15)
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ELKS (N-15): sc-47876. Western blot analysis of ELKS expression in mouse testis tissue extract.
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