epitope mapping near the N-terminus of CARD 10 of human origin
recommended for detection of CARD 10 of mouse and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and bovine
CARD 10 Background Information Membrane-associated guanylate kinase (MAGUK) family members function as molecular scaffolds for the assembly of multiprotein complexes localizing to the plasma membrane. Several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product belong to the MAGUK family, including the caspase recruitment domain (CARD) protein family with the exception of CARD9. The CARD domain consists of 6 or 7 antiparallel alpha helices. CARD family members participate in apoptosis signaling through highly specific protein-protein homophilic interactions. CARD 10 (also designated CARD-containing MAGUK protein 3 or Carma 3) interacts with BCL-10 to activate NF˚B. CARD10 is expressed in a variety of adult and fetal tissues, including heart, kidney and liver, and in multiple cancer cell lines.
