Polycystin-2 Antibody (YCE2): sc-47734

Polycystin-2 Antibody (YCE2) is a mouse monoclonal IgG2b kappa light chain antibody targeting Polycystin-2, also known as PKD2, TRPP2, or PC2, with confirmed reactivity in human, rat, and mouse samples across western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) assays. Polycystin-2 is a membrane-associated glycoprotein that primarily localizes to the endoplasmic reticulum and plasma membrane, where Polycystin-2 plays a crucial role in calcium ion transport and cellular signaling. The localization of Polycystin-2 at these cellular sites is significant, as Polycystin-2 regulates calcium homeostasis and thus influences cell proliferation, differentiation, and survival. Polycystin-2′s proper function is essential for kidney health, and mutations in the PKD2 gene are associated with autosomal dominant polycystic kidney disease (ADPKD), contributing to cyst formation in kidney tubules. Polycystin-2 is known to interact with Polycystin-1, forming a complex that enhances AP-1 expression, which is critical for modulating gene expression linked to cell growth and apoptosis. Available as both a non-conjugated antibody and in various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, anti-Polycystin-2 antibody (YCE2) enables precise detection and investigation of Polycystin-2′s role in kidney pathology and other cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Polycystin-2 Antibody (YCE2) has 21 citations in a variety of scientific publications.

Primary antibodies like Anti-Polycystin-2 Antibody (YCE2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Polycystin-2 Antibody (YCE2) Specifications

Alternate Product Name: Polycystin-2

Product Clone Name: YCE2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 687-754

Epitope Target: Polycystin-2

Epitope Species: human

Product Reactivity/Detection: Polycystin-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 21 citations in various scientific publications

Available Conjugates/Forms for Polycystin-2 Antibody (YCE2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Polycystin-2 antibody is Polycystin-2 Antibody (D-3): sc-28331.