ADAMTS-1 Background Information ADAMTS-1, also known as METH-1, C3-C5 and KIAA1346, and the related protein ADAMTS-8, also known as METH-2 and FLJ41712, represent a new family of proteins with metalloprotease, disintegrin and Thrombospondin domains. ADAMTS-1 and ADAMTS-2 are secreted and proteolytically processed proteins that are 51.7% identical but display different, non-overlapping patterns of expression in tissues and cultured celllines. Both ADAMTS proteins have been shown to be more active than Thrombospondin-1 or endostatin in preventing angiogenesis in a cornea pocket model, and both may have application for the inhibition of new blood vessel formation in a range of tumor types. The spacer region and the Thrombospondin type I motifs in the carboxy-terminus of ADAMTS-1 are important for anchoring ADAMTS-1 to the extracellular matrix.
ADAMTS-1 (3C8F4)
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ADAMTS-1 (3C8F4): sc-47727. Western blot analysis of unreduced 87 kDa human recombinant ADAMTS-1 purified from transfected 293T cells.
ADAMTS-1 (3C8F4): sc-47727. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing cytoplasmic staining of a subset of lymphoid cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
