epitope mapping near the C-terminus of SMC5 of human origin
recommended for detection of SMC5 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
TransCruz reagent for Gel Supershift and ChIP applications, sc-47627 X, 200 µg/0.1 ml
SMC5 Background Information Breaks in double stranded DNA often arise during DNA replication or as a result of exposure to DNA-damaging agents. Quick and accurate repair of these breaks is crucial for cell survival and genomic stability. Structural maintenance of chromosomes (SMC) family members form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation during mitosis. Two distinct SMC protein complexes are the SMC1/SMC3 heterodimer and the SMC2/SMC4 heterodimer. SMC5 and SMC6 play a crucial role in DNA repair as they form a complex that, along with SUMO ligase, is also important in preventing DNA damage-induced apoptosis. This complex made up of SMC5 and SMC6 is crucial for sister chromatid homologous recombination DNA repair and also for prevention of chromosomal rearrangements.
