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PARN Antibody (N-12): sc-47618

 |  Datasheet

(Based on data analysis)
  • PARN Antibody (N-12) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping near the N-terminus of PARN of human origin
  • recommended for detection of PARN of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-47618 X, 200 µg/0.1 ml
  • blocking peptide, sc-47618 P
 

See additional PARN Antibodies.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   Gel Shift   ChIP   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
PARN Antibody (N-12) sc-47618 200 µg/ml $279
PARN (N-12) P sc-47618 P
(peptide)
 100 µg/0.5 ml $61
PARN Antibody (N-12) X sc-47618 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PARN siRNA (h) sc-61297 10 µM $258
PARN siRNA (m) sc-61298 10 µM $258
PARN (h)-PR sc-61297-PR 10 µM, 20 µl $23
PARN (m)-PR sc-61298-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PARN shRNA Plasmid (h) sc-61297-SH 20 µg $520
PARN shRNA Plasmid (m) sc-61298-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PARN shRNA (h) Lentiviral Particles sc-61297-V 200 µl $625
PARN shRNA (m) Lentiviral Particles sc-61298-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PARN 5073 16p13.12 NM_002582 O95453
 604212
Mouse Parn 74108 16 A1 Q8VDG3
 N/A
 

Exonucleolytic degradation of the poly(A) tail often initiates the first step in the decay of eukaryotic mRNAs. Poly(A)-specific ribonuclease (PARN), a highly poly(A)-specific 3'-exoribonuclease, efficiently degrades mRNA poly(A) tails. PARN, which also may be designated deadenylating nuclease, may also be involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons, and in the degradation of inherently unstable mRNAs that contain au-rich elements (AREs) in their 3' untranslated regions. PARN, which can form a homodimer, interacts with KHSRP and can be found in a mRNA decay complex with RENT1, RENT2 and RENT3B.It localizes mainly to the nucleus (may be detected in the nucleolus), but may also localize to the cytoplasm.