Jumonji Background Information Jumonji, a nuclear protein crucial for neural tube formation, plays an important role in downregulating atrial natriuretic factor (ANF) gene expression through its interaction with GATA4 and NKX2-5. Required for normal development of the heart, jumonji participates in negatively regulating the signaling involved in cell proliferation. Jumonji, also designated ARID domain-containing protein 2, is a member of the JMJ transcription factor family of proteins. During emryogenesis, jumonji, which localizes to the nucleus, is expressed primarily in neurons, especially dorsal root ganglion cells.
