FOXQ1 Background Information The FOX family of transcription factors share a common DIUA binding domain termed a winged-helix or forkhead domain. Many FOX proteins play important roles in development, metabolism, cancer and aging. FOXQ1 is mutant in satin homozygous mice. Satin mice are characterized by having silky coats with high sheen as a result of structurally abnormal medulla cells and defects in the differentiation of the hair shaft. Satin mice also display suppressed natural killer cell function and alloimmune cytotoxic T-cell function, which implicates FOXQ1 in lymphocyte development. FOXQ1 is predominantly expressed during embryogenesis and in a tissue-restricted expression pattern in adult tissues, including stomach, trachea, bladder and salivary gland. FOXQ1 is overexpressed in colorectal adenocarcinoma and lung carcinoma cell lines.
FOXQ1 (C-16)
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FOXQ1 (C-16): sc-47596. Western blot analysis of FOXQ1 expression in non-transfected: sc-117752 (A) and human FOXQ1 transfected: sc-116439 (B) 293T whole cell lysates.
FOXQ1 (C-16): sc-47596. Western blot analysis of FOXQ1 expression in non-transfected: sc-117752 (A) and mouse FOXQ1 transfected: sc-120313 (B) 293T whole cell lysates.
FOXQ1 (C-16): sc-47596. Western blot analysis of FOXQ1 expression in non-transfected: sc-117752 (A) and human FOXQ1 transfected: sc-116439 (B) 293T whole cell lysates.
