epitope mapping within an N-terminal cytoplasmic domain of TRPV4 of human origin
recommended for detection of TRPV4 isoforms 1, 2, and 3 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
TRPV4 Background Information The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology, not activating stimuli: C type (canonical or classical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD). TRPV4, also designated VRL-2, TRP12, VR-OAC and OTRPC4, belongs to the V type subfamily, and plays a role in systemic osmoregulation. TRPV4 is a calcium channel activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity. TRPV4 is highly expressed in lung and kidney.
