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home » Growth Factors and Hormones » SIGIRR Antibody / SIGIRR Antibodies » SIGIRR (C-12): sc-47405

SIGIRR (C-12) Antibody: sc-47405

  |  Datasheet
  • goat polyclonal IgG, 200µg/ml
  • epitope mapping at the C-terminus of SIGIRR of human origin
  • recommended for detection of SIGIRR of mouse, rat and human origin by WB, IP, IF and ELISA
  • blocking peptide, sc-47405 P
 
Additional SIGIRR Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SIGIRR 59307 11p15.5 NM_021805 Q6IA17
 605478
Mouse Sigirr 24058 7 F5 Q9JLZ8
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
SIGIRR (C-12) sc-47405 200 µg/ml $279
SIGIRR (C-12) P sc-47405 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SIGIRR siRNA (h) sc-61547 10 µM $258
SIGIRR siRNA (m) sc-61548 10 µM $258
SIGIRR (h)-PR sc-61547-PR 10 µM $23
SIGIRR (m)-PR sc-61548-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SIGIRR shRNA Plasmid (h) sc-61547-SH 20 µg $520
SIGIRR shRNA Plasmid (m) sc-61548-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SIGIRR shRNA (h) Lentiviral Particles sc-61547-V 200 µl $625
SIGIRR shRNA (m) Lentiviral Particles sc-61548-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MDCK Cell Lysate sc-2252 500 µg/200 µl $104
Ramos Cell Lysate sc-2216 500 µg/200 µl $104
A549 Cell Lysate sc-2413 500 µg/200 µl $104
Caki-1 Cell Lysate sc-2224 500 µg/200 µl $104
SIGIRR (h): 293T Lysate sc-111731 100µg/200µl $205
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

SIGIRR Background Information
Single Ig IL-1-related receptor, SIGIRR, also designated single immunoglobulin domain-containing IL-1R-related protein or Toll/interleukin-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor family. SIGIRR acts as a negative regulator of the IL-1R and Toll-like receptor signaling pathways and reduces the recruitment of certain components to the TLR4 receptor. Subsequently, SIGIRR confers resistance to P. aeruginosa corneal infection. SIGIRR can form complexes with IL-1R1, MYD-88, IRAK-1 and TRAF-6 upon IL-1 stimulation and TLR4 after LPS stimulation. It is a single-pass type III membrane protein that is mainly expressed in kidney, lung and gut.
SIGIRR (C-12)
Click on image to enlarge
sc-47405
SIGIRR (C-12): sc-47405. Western blot analysis of SIGIRR expression in MDCK (A), Ramos (B), A549 (C) and Caki-1 (D) whole cell lysates.
sc-47405
SIGIRR (C-12): sc-47405. Western blot analysis of SIGIRR expression in non-transfected: sc-117752 (A) and human SIGIRR transfected: sc-111731 (B) 293T whole cell lysates.
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