epitope mapping near the C-terminus of Perilipin of human origin
recommended for detection of Perilipin of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
Perilipin Background Information The PAT (Perilipin, adipophilin, TIP47) family proteins are evoluntionary related proteins associated with lipid droplets and implicated in intracellular lipid metabolism. The phosphoprotein Perilipin (Peri), also designated lipid droplet-associated protein, belongs to the Perilipin subfamily of proteins. Perilipin localizes on the surface of intracellular lipid droplets within adipocytes, where it protects lipid storage droplets by coating them in adipocytes until they are digested by hormone sensitive lipase (HSL), thereby modulating adipocyte lipid metabolism. As a critical regulator of lipolysis, elevated Perilipin levels have been linked to obesity, as the absence results in leanness. In its phosphorylated state, Perilipin is maximally sensitive to HSL.
