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PAPP-A Antibody (C-14): sc-47300

 |  Datasheet

(Based on data analysis)
  • PAPP-A Antibody (C-14) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the C-terminus of PAPP-A of human origin
  • recommended for detection of PAPP-A of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-47300 P
 

See additional PAPP Antibodies including PAPP, PAPP-A and PAPP-A2.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
PAPP-A Antibody (C-14) sc-47300 200 µg/ml $279
PAPP-A (C-14) P sc-47300 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PAPP-A siRNA (h) sc-61289 10 µM $258
PAPP-A siRNA (m) sc-61290 10 µM $258
PAPP-A (h)-PR sc-61289-PR 10 µM, 20 µl $23
PAPP-A (m)-PR sc-61290-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PAPP-A shRNA Plasmid (h) sc-61289-SH 20 µg $520
PAPP-A shRNA Plasmid (m) sc-61290-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PAPP-A shRNA (h) Lentiviral Particles sc-61289-V 200 µl $625
PAPP-A shRNA (m) Lentiviral Particles sc-61290-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PAPPA 5069 9q33.1 NM_002581 Q13219
 176385
Mouse Pappa 18491 4 C1 Q8R4K8
 N/A
 

Pregnancy-associated plasma protein-A (Pappalysin-1 or PAPP-A), also known as Insulin-like growth factor-dependent IGF-binding protein 4 (IGFBP4) protease, is a member of the peptidase M43B family of proteins. PAPP-A, a metalloproteinase, cleaves Insulin-like growth factor binding proteins IGFBP4 and IGFBP5, releasing bound IGF. PAPP-A is primarily expressed in septa and anchoring villi in placenta and is also expressed in pregnancy serum. Levels of PAPP-A increase throughout pregnancy. Lower levels of expression can be detected in kidney, prostate, breast, ovary and endometrial tissues. PAPP-A is a secreted protein that can form homodimers; in pregnancy serum PAPP-A may also form a heterotetramer with PRG-2.