epitope mapping near the C-terminus of MRTF-B of human origin
recommended for detection of MRTF-B isoforms 1 and 4 of mouse and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
MRTF-B Background Information Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
MRTF-B (C-19) Product Citations
See how others have used MRTF-B (C-19): sc-47282 antibody and or MRTF-B (C-19) antibody conjugates.
