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GW182 Antibody (C-19): sc-47034

 |  Datasheet

(Based on data analysis)

  • GW182 Antibody (C-19) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping near the C-terminus of GW182 of human origin
  • recommended for detection of GW182 isoforms 1, 2 and 3 only of mouse and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and avian
  • blocking peptide, sc-47034 P
 

See additional GW182 Antibodies.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
GW182 Antibody (C-19) sc-47034 200 µg/ml $279
GW182 (C-19) P sc-47034 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GW182 siRNA (h) sc-45516 10 µM $258
GW182 siRNA (m) sc-45517 10 µM $258
GW182 siRNA (h)-PR sc-45516-PR 10 µM, 20 µl $23
GW182 siRNA (m)-PR sc-45517-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GW182 shRNA Plasmid (h) sc-45516-SH 20 µg $520
GW182 shRNA Plasmid (m) sc-45517-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GW182 siRNA shRNA (h) Lentiviral Particles sc-45516-V 200 µl $625
GW182 siRNA shRNA (m) Lentiviral Particles sc-45517-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TNRC6A 27327 16p12.1 NM_014494, NM_020847 Q8NDV7
 610739
Mouse Tnrc6a 233833 7 F3 NP_659174
 N/A
 

GW bodies (GWBs) function as storage centers and degradation sites for mRNAs. GWBs are crucial intracellular structures for miRNA function. Dis-assembly or disruption of GWBs has been shown to impair siRNA and miRNA silencing activity. GW182 is a cytoplasmic marker protein for GWBs. GW182 autoantigen, also designated EMSY interactor protein, plays a role in the maintenance and stability of the GWB structures. GW182 is a ubiquitously expressed protein that binds to mRNA. The GW182 protein may interact with endogenous argonaute-2 (Ago2), which is also enriched in GWBs. The GW182 protein is detected in patients with ataxia, Sjoegren’s syndrome (SS) and sensor neuropathy disease, who develop autoantibodies against GWB structure proteins.

GW182 Antibody (C-19) Data
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sc-47034
GW182 (C-19): sc-47034. Western blot analysis of GW182 expression in non-transfected: sc-117752 (A) and human GW182 transfected: sc-113721 (B) 293T whole cell lysates.
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