epitope mapping near the C-terminus of BRD3 of human origin
recommended for detection of BRD3 isoform 1 of mouse, rat and human origin by WB, IF and ELISA; may cross-react with BRD2; also reactive with additional species, including equine, canine, bovine, porcine and avian
BRD3 Background Information The bromodomain-containing proteins include BRD2, BRD3, BRD4 and BRDT. BRD2 (RING3 protein) is a mitogen-activated nuclear protein whose gene is located in the human MHC II region, suggesting its relation to HLA-associated diseases. The gene encoding BRD3 (RING3-like protein) contains two bromodomains and maps to chromosome 9q34. BRD4 (HUNK1 protein) is a nuclear protein involved in the regulation of chromosomal dynamics during mitosis. The testis-specific bromodomain protein BRDT contains a PEST sequence, indicating that it undergoes rapid intracellular degradation. The bromodomain-containing proteins are ubiquitously expressed.
