epitope mapping near the N-terminus of BChE of human origin
recommended for detection of mature BChE and Cholinesterase precursor of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
BChE Background Information Present in most cells except erythrocytes, butyrylcholine esterase (BChE), also designated acylcholine acylhydrolase or pseudocholinesterase, has esterase activity as well as aryl acylamidase activity. It hydrolyzes acylcholine into choline and carboxylate. BChE is synthesized in the liver and is highly reactive with organophosphate esters. BChE can form a homotetramer composed of two dimers linked by a disulfide bond. Defects in the gene encoding BChE are associated with the disease hypocholinesterasemia. Inhibition of BChE effects the toxicity of organophosphates in the respiratory system suggesting that BChE may play a role in respiratory function. In addition, BChE may play an important pharmocological role by hydrolyzing toxic esters. This suggests an involvement of BChE in a treatment for intoxication with substances such as cocaine.
BChE (N-15)
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BChE (N-15): sc-46803. Western blot analysis of BChE expression in non-transfected: sc-117752 (A) and human BChE transfected: sc-113260 (B) 293T whole cell lysates.
BChE (N-15): sc-46803. Western blot analysis of BChE expression in SK-MEL-24 (A), C32 (B), LADMAC (C) and c4 (D) whole cell lysates and mouse liver (E) and rat liver (F) tissue extracts.
